Brain+ A/S announces the exercise price for its warrants of series TO 2

COMPANY ANNOUNCEMENT Copenhagen, Denmark, September  29, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) NOT FOR RELEASE, DISTRIBUTION OR PUBLICATION, DIRECTLY OR INDIRECTLY, IN OR INTO, THE UNITED STATES OF AMERICA, AUSTRALIA, BELARUS, CANADA, HONG KONG, JAPAN, NEW ZEALAND, RUSSIA, SINGAPORE, SOUTH AFRICA, SOUTH KOREA, SWITZERLAND OR ANY OTHER JURISDICTION IN WHICH THE RELEASE, DISTRIBUTION OR PUBLICATION WOULD BE UNLAWFUL OR REQUIRE REGISTRATION OR ANY OTHER MEASURE. · The exercise price of the TO 2 warrants has been set at DKK 0.20 · The exercise period for the TO 2 warrants runs from 2-16 October 2023 · The TO 2 warrants are tradable with the last day of trading set to 12 October 2023

Notice of Extraordinary General Meeting

Summary of H1 2023 report: Brain+ has closed new sales contracts, built key customer engagement, developed a new product concept, achieved technology validations and secured new funding

Brain+ A/S (BRAINP) - Company Announcement Thursday, August 31, 2022, 8:30 CET Today, Brain+ has released its financial report for the period 1 January - 30 June 2023 (unaudited) including a business update for the year to date.

Brain+ A/S carries out a directed issue as compensation to guarantors of its unit rights issue

COMPANY ANNOUNCEMENT Copenhagen, Denmark, June 12, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) NOT FOR RELEASE, DISTRIBUTION OR PUBLICATION, DIRECTLY OR INDIRECTLY, IN OR INTO, THE UNITED STATES OF AMERICA, AUSTRALIA, BELARUS, CANADA, HONG KONG, JAPAN, NEW ZEALAND, RUSSIA, SINGAPORE, SOUTH AFRICA, SOUTH KOREA, SWITZERLAND OR ANY OTHER JURISDICTION IN WHICH THE RELEASE, DISTRIBUTION OR PUBLICATION WOULD BE UNLAWFUL OR REQUIRE REGISTRATION OR ANY OTHER MEASURE.

Brain+ A/S announces the first day of trading for the new shares and warrants from its rights issue

COMPANY ANNOUNCEMENT Copenhagen, Denmark, June 9, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) NOT FOR RELEASE, DISTRIBUTION OR PUBLICATION, DIRECTLY OR INDIRECTLY, IN OR INTO, THE UNITED STATES OF AMERICA, AUSTRALIA, BELARUS, CANADA, HONG KONG, JAPAN, NEW ZEALAND, RUSSIA, SINGAPORE, SOUTH AFRICA, SOUTH KOREA, SWITZERLAND OR ANY OTHER JURISDICTION IN WHICH THE RELEASE, DISTRIBUTION OR PUBLICATION WOULD BE UNLAWFUL OR REQUIRE REGISTRATION OR ANY OTHER MEASURE.

Brain+ A/S announces a delay of the first day of trading for the new shares from its rights issue

Brain+ A/S published the outcome of its rights issue of units

COMPANY ANNOUNCEMENT Copenhagen, Denmark, May 30, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) NOT FOR RELEASE, DISTRIBUTION OR PUBLICATION, DIRECTLY OR INDIRECTLY, IN OR INTO, THE UNITED STATES OF AMERICA, AUSTRALIA, BELARUS, CANADA, HONG KONG, JAPAN, NEW ZEALAND, RUSSIA, SINGAPORE, SOUTH AFRICA, SOUTH KOREA, SWITZERLAND OR ANY OTHER JURISDICTION IN WHICH THE RELEASE, DISTRIBUTION OR PUBLICATION WOULD BE UNLAWFUL OR REQUIRE REGISTRATION OR ANY OTHER MEASURE. The subscription period in Brain+ A/S’ (“Brain+” or the “Company”) rights issue of units with pre-emptive subscription rights for existing shareholders, in which the public also was given the opportunity to participate, ended on May 25, 2023. The rights issue was subscribed to a total of approximately 88 percent, including pre-subscription and guarantee commitments. Brain+ will thus be provided proceeds of approximately DKK 13.8 million before deduction of transaction related costs. As a result of the outcome, the option of an over-allotment issue will not be used. The outcome of the rights issue of units ensures that Brain+ can continue investing in the commercial build-up for its first marketed digital dementia product and in maturing its clinical pipeline of more advanced product options. Formal decision on unit allocation is estimated to take place on May 31, 2023.

Minutes of the Annual General Meeting 2023 in Brain+ A/S

On Friday 26[th] of May at 08:00 CET, Brain+ A/S held its Annual General Meeting. The meeting was held at the company’s home address at Købmagergade 53, 3. 1150 Copenhagen with the following agenda:

Notice of Annual General Meeting of Brain+ A/S

Invitation to Annual General Meeting The shareholders of Brain+ A/S are hereby invited to attend the Annual General Meeting scheduled for Friday, 26th of May 2023, at 08:00 am. The general meeting will take place at the company’s address at Købmagergade 53, 3., 1150 Copenhagen as a physical event.

The subscription period in Brain+ rights issue begins today

COMPANY ANNOUNCEMENT Copenhagen, Denmark, May 10, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) NOT FOR RELEASE, DISTRIBUTION OR PUBLICATION, DIRECTLY OR INDIRECTLY, IN OR INTO, THE UNITED STATES OF AMERICA, AUSTRALIA, BELARUS, CANADA, HONG KONG, JAPAN, NEW ZEALAND, RUSSIA, SINGAPORE, SOUTH AFRICA, SOUTH KOREA, SWITZERLAND OR ANY OTHER JURISDICTION IN WHICH THE RELEASE, DISTRIBUTION OR PUBLICATION WOULD BE UNLAWFUL OR REQUIRE REGISTRATION OR ANY OTHER MEASURE

Brain+ A/S publishes supplement to prospectus

Brain+ publishes its Annual Report 2022, highlighting important milestones and financial performance as expected

COMPANY ANNOUNCEMENT  Copenhagen, Denmark, April 28, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) Brain+, a digital dementia therapeutics company, has today published its annual report for 2022, including  

Annual Report 2022 for Brain+ A/S

Brain+ annual report for 2022 is now available on the Company´s website

Brain+ A/S (BRAINP) announces management changes

COMPANY ANNOUNCEMENT Copenhagen, Denmark, April 25, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) Brain+ informs that its Chief Financial Officer (“CFO”), Bertil S. Jessen, will be taking a one-year leave of absence for family reasons starting in May 2023.

Approval and publication of prospectus

COMPANY ANNOUNCEMENT Copenhagen, Denmark, April 24, 2023 – Brain+ A/S (Nasdaq First North: BRAINP)

The Board of Directors in Brain+ A/S has resolved on the previously announced intention to execute a rights issue of units

COMPANY ANNOUNCEMENT Copenhagen, Denmark, April 24, 2023 – Brain+ A/S (Nasdaq First North: BRAINP)

Minutes of Extraordinary General Meeting Brain+ A/S

Notice of Extraordinary General Meeting of Brain+ A/S

Notice is hereby given for an Extraordinary General Meeting in Brain+ A/S, CVR. No. 36439440 (“Company”) to be held Thursday, 13 April 2023 at 3 PM (15:00 CEST). The Extraordinary General Meeting will be held at the Company’s registered address at: Købmagergade 53, 3 1150 København K, Denmark.

The Board of Directors in Brain+ A/S intends to execute a rights issue of units of approximately DKK 15.7 million in order to intensify commercial activities

COMPANY ANNOUNCEMENT Copenhagen, Denmark, March 29, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) NOT FOR RELEASE, DISTRIBUTION OR PUBLICATION, DIRECTLY OR INDIRECTLY, IN OR INTO, THE UNITED STATES OF AMERICA, AUSTRALIA, BELARUS, CANADA, HONG KONG, JAPAN, NEW ZEALAND, RUSSIA, SINGAPORE, SOUTH AFRICA, SOUTH KOREA, SWITZERLAND OR ANY OTHER JURISDICTION IN WHICH THE RELEASE, DISTRIBUTION OR PUBLICATION WOULD BE UNLAWFUL OR REQUIRE REGISTRATION OR ANY OTHER MEASURE. Today, the Board of Directors in Brain+ A/S (“Brain+” or the “Company”) has resolved to carry out a preferential rights issue of units, consisting of shares and warrants of series TO 2 and TO 3 (the “Rights Issue”). The Rights Issue is subject to the general meeting authorizing the Board of Directors to complete the Rights Issue which is expected to take place at an extraordinary general meeting to be held on 13 April 2023 and the Board of Directors formal board decision to execute the Rights Issue. Provided that the Rights Issue is fully subscribed, the Company will initially receive approximately DKK 15.7 million, whereof approximately DKK 3.7 million already has been received by agreed bridge loan in March 2023, before deduction of transaction related costs. The Rights Issue is through subscription- and guarantee commitments secured to approximately DKK 13.4 million, corresponding to approximately 85 percent of the issue volume. The Board of Directors may carry out an over-allotment issue of approximately DKK 5.8 million if the Rights Issue is oversubscribed (the “Over-Allotment Issue”). In addition, Brain+ has secured a bridge loan of approximately DKK 3.7 million. The loan will be converted in full, plus a premium of 20 percent, into units in the Rights Issue. Notice to the extraordinary general meeting will be published in a separate company announcement.

Successful conclusion of EU project Alzheimer’s Detect & Prevent with early validation of two Brain+ DTx technologies and extra funding

Company Announcement Copenhagen, Denmark, February 8, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) The information communicated in this announcement is “inside information” for the purposes of article 7 of the Market Abuse Regulation 596/2014 · The ‘Alzheimer’s Detect & Prevent’ project, led by Brain+ and funded under the EU Horizon2020 innovation framework, has been approved by the European Commission · The project has funded the development and early clinical feasibility testing of two key Brain+ technologies: 1) the ‘Starry Night’ cognitive test and 2) 1[st] generation Computerized Cognitive Training (CCT) for the reduction of mental workload · The indications of clinical feasibility of the CCT technology and the Starry Night cognitive test provide early support for the company's pipeline ‘CST for MCI’ product for Mild Cognitive Impairment, which combines CCT, Starry Night, and Cognitive Stimulation Therapy (CST) · The final review by the European Commission resulted in Brain+ securing an additional payment of €110.000 above the original budget to Brain+ for work rendered and results obtained.

Warrants of Series TO1 expected subscribed to approximately 82% of the offered amount and Brain+ A/S to receive approximately DKK 6,4m before issuing costs

Company Announcement Copenhagen, Denmark October 31, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) Brain+ A/S (“Brain+” or the “Company”) today announces the preliminary outcome of the exercise of warrants of series TO1 (the “Warrants”), which were issued in connection with the Company’s IPO on Nasdaq First North Growth Market, Denmark in October 2021. In total, 3.904.606 Warrants have been exercised to subscribe for 3.904.606 new shares at the exercise price of DKK 1.638 per share. Brain+ is expected to receive approximately DKK 6,4m before issuing costs, through the exercise of the Warrants.

Brain+ CEO and Board members exercise IPO warrants to subscribe for new shares in Brain+ A/S for DKK 0.5m

Company Announcement Copenhagen, Denmark, October 17, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) The information communicated in this announcement is “inside information” for the purposes of article 19 of the Market Abuse Regulation 596/2014 On October 17[th] 2022, Kim Baden-Kristensen, CEO & Co-founder of Brain+ A/S (“Brain+) and members of the board of Brain+, Lars Terney, Vice Chairman, and Hanne Leth Hillman, Chair of the Audit Committee (collectively “the Investors”), chose to exercise all of their warrants of series TO 1 (BRAINP TO, ISIN: DK0061670551), to subscribe for newly issued shares in Brain+ A/S.

Brain+ announces details on the exercise of IPO warrants to subscribe for new shares, including the exercise price for the warrants

Company Announcement Copenhagen, Denmark, October 14, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) In connection with Brain+’s IPO in October 2021, the company issued 4.8m publicly traded warrants, which can be exercised to subscribe for new shares in Brain+ A/S between October 17[th] and October 31[st] 2022, at an exercise price of DKK 1,638 per share. Please find relevant information and terms on the Brain+ website (www.brain-plus.com).

The pricing period for Brain+’s warrants of series TO 1 is underway

Company Announcement Copenhagen, Denmark October 7, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) The pricing period for Brain+’s warrants of series TO 1 (BRAINP TO, ISIN: DK0061670551) is underway. These warrants will from October 17[th] to October 31[st] be exercisable into newly issued Brain+ A/S shares at a 30% discount to the volume-weighted average price of shares traded from October 3[rd] to October 14[th], 2022.

Interim Report for the Period 1. January 2022 – 30. June 2022

Company Announcement Thursday, September 29, 2022, 10:00 CET Brain+ A/S (“Brain+”) [BRAINP], today publishes the Interim Report for the Period 1. January 2022 – 30. June 2022

Brain+ A/S appoints Anders Härfstrand as new Chairman of the Board

Company Announcement Monday, September 5, 2022, 10:00 CET The information communicated in this announcement is “inside information” for the purposes of article 7 of the Market Abuse Regulation 596/2014 Brain + A/S (“Brain+”) today announced Anders Härfstrand, who was elected to the board of directors at the company’s Extraordinary General Meeting on September 2, 2022, has been appointed new Chairman of the Board.  Anders Härfstrand has extensive international life science industry and leadership experience, and succeeds Lars Terney, who continues on the board as Vice Chairman after having served as Chairman for the past year.[ ] 

Brain+ announces results of Extraordinary General Meeting of Shareholders

Copenhagen, Denmark – 2 September 2022 – Brain+ A/S (“Brain+”) [BRAINP], today announced the results of the Extraordinary General Meeting of Shareholders of Brain+ (“EGM”) which was held on 2 September 2022.

Brain+ A/S intends to add three international life science profiles as new board members in a strategic move ahead of its near-term commercial launch

Monday, August 8, 2022, 8:30 CET The Board of Directors of Brain+ A/S (“Brain+”) hereby notifies of its intention to convene an Extraordinary General Meeting (“EGM”) on Friday, September 2, 2022. The purpose of the EGM is the election of three new board members, nominated as candidates by the Board of Directors: Anders Härfstrand, Chairman of Diurnal Group, Johan Luthman, EVP & Head of R&D at Lundbeck, and Betül Susamis Unaran, Member of the Board of Directors of Ypsomed. The candidates represent a valuable span of international competencies of high relevance for Brain+’s near-term move into commercialization and subsequent business expansion.

Notice of Extraordinary General Meeting of Brain+ A/S

The shareholders of Brain+ A/S are hereby invited to attend an Extraordinary General Meeting on Friday 2[nd] September 2022 at 09:00 (CEST). The Extraordinary General Meeting will take place at Købmagergade 53, 3. 1150 Copenhagen as a physical event.

Minutes of the Annual General Meeting 2022 in Brain+ A/S

On Wednesday 18th of May at 14:00 CET Brain+ A/S held its Annual General Meeting at Hauser Pl. 20, 5., 1127 København.

Notice of Annual General Meeting of Brain+ A/S and Change to the Board of Directors

Invitation to Annual General Meeting The shareholders of Brain+ A/S are hereby invited to attend the Annual General Meeting scheduled for 18th May 2022, 14:00. The general meeting will be take place at Hauser Pl. 20, 5., 1127 København as a physical event.

Annual Report 2021 for Brain+ A/S

Brain+ annual report for 2021 is now available on the Company´s website

Positive results from the first of four clinical studies to evaluate Brain+’ Starry Night cognitive test for early detection of Alzheimer’s Disease

BRAIN+ A/S (BRAINP) Company Announcement No. 2-2022 Thursday, February 3., 2022, 09:00 CET The information communicated in this announcement is “inside information” for the purposes of article 7 of the Market Abuse Regulation 596/2014

Brain+ A/S (BRAINP) appoints Chief Financial Officer

BRAIN+ A/S (BRAINP) Company Announcement No. [1-2022] [Thursday January 27, 2022, 17:00 CET]

Brain+ lands first large-pharma partnership deal to enter the German market for dementia products

BRAIN+ A/S (BRAINP) Company Announcement No. 4-2021 Wednesday, December 15, 2021, 8:20 CET The information communicated in this announcement is “inside information” for the purposes of article 7 of the Market Abuse Regulation 596/2014 Brain+ has signed a partnership agreement with RoX Health (https://roxhealth.com/), a subsidiary of the global pharma company Roche in Germany, to bring its first dementia products to the German market.

Board member announces intention to leave board

BRAIN+ A/S (BRAINP) Company Announcement No. 3-2021 Tuesday November 16, 2021, 22:05 CET

Brain+ IPO 169% subscribed by 1,288 investors

The total subscription in the IPO was DKK 25.4 million from a total of 1,288 subscribers, translating into a subscription percentage of 169% counting all shares offered in the offering.

Danish Digital Medicine Company Brain+ Goes Public

THURSDAY, SEP 16, 2021 Brain+ A/S is offering Units and has applied for admission to trading on Nasdaq First North Growth Market Denmark.  

Brain+ has convened an EGM to add a strong digital health industry profile to its board of directors

Tuesday, September 26, 2023, 8:45 CET – Brain+ A/S (Nasdaq First North: BRAINP) · Anish Shindore, a global digital health industry heavyweight with strong commercial and partnering experience as well as a vast DTx stakeholder network, has accepted to join Brain+ as new board member

Brain+ online investor meeting: Status update, warrant exercise and Q&A

Copenhagen, Denmark, September 22, 2023 – Brain+ A/S (Nasdaq First North: BRAINP)

Brain+ awarded an EUopSTART grant by the Danish Innovation Fund to support 2[nd] stage of its EIC Accelerator application

Copenhagen, Denmark, September 20, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) · The EUopSTART grant of up to DKK 50,000 will fund the preparations of a 2[nd] stage application for the large EIC Accelerator grant · Earlier this month, Brain+’ EIC Accelerator application for up to DKK 60 million in funding for the CST-Home Care project passed the 1[st] evaluation round with unanimous evaluator support   · The 2[nd] stage application will be submitted in October, and an answer to the application is expected in December 2023

Brain+ to present at DTx East 2023, a global summit for the digital therapeutics’ community, held in Boston, US on 26-28 September

Copenhagen, Denmark, September 13, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) · Brain+ founder and CEO, Kim Baden-Kristensen has been invited to give a keynote presentation at the conference on the topic of “Truly Defining Digital Therapeutics”   · The DTx conference series is the main meeting point for all key stakeholders in the global digital therapeutics’ community

Two Brain+ grant applications pass first evaluation gate with unanimous support from evaluators

Copenhagen, Denmark, September 13, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) · The EIC Accelerator application of DKK 60 million in grant and equity funding, submitted in late August to support the CST-Home Care product, has passed to the 2[nd] and final evaluation round with unanimous evaluator support · The application for a DKK 4 million CO-PI grant also submitted in August to support the implementation of CST-Therapist Companion in Denmark, has passed the first screening and expanded answers have been submitted · For both grants, as well as for the InnoBooster grant, final answers are expected in Q4 2023

Brain+ secures intellectual property rights for CST-Therapist Companion in the EU and the United Kingdom

Copenhagen, Denmark, September 8, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) · Key design and user interface elements of CST-Therapist Companion now legally protected in the company’s first target markets via design protections · Protection of IP rights, including design elements, is very important to secure the value of a digital therapeutic and its competitive market position as well as to attract partnership agreements

Brain+ has submitted new public grant applications to raise up to DKK 67 million to develop and scale its digital dementia products

Copenhagen, Denmark, August 25, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) · Dementia is a field of substantial unmet needs and high political awareness, and Brain+ has a long history of successfully raising public funding to support its R&D activities · New application submitted for a Danish InnoBooster grant of DKK 3 million to complete the development of CST-Therapist Companion v2.0 · New application submitted for a CO-PI grant of DKK 4 million to support the implementation of CST-Therapist Companion in Denmark and the UK as well as in the official CST education · New application submitted for an EU EIC Accelerator grant of DKK 17 million and DKK 43 million in equity funding from the European Central Bank to develop, market and commercially scale Brain+’ CST-Home Care product

Brain+ Online Investor Update

Copenhagen, Denmark, May 22, 2023 – Brain+ A/S (Nasdaq First North: BRAINP)

Brain+ and Danish municipalities are advancing the development of version 2.0 of the CST-Therapist Companion

Copenhagen, Denmark, August 9, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) · Since the introduction of CST-Therapist Companion v1.0 in Denmark, Brain+ has been met with a keen interest in its digital CST approach from several Danish municipalities · Municipal dementia coordinators who work with CST have joined Brain+ focus groups to provide valuable user input and concept feedback for the next version of the product · The CST-Therapist Companion v2.0 will offer upgraded technical features as well as new scalable and customizable CST content, allowing therapists to tailor the therapy to each CST group    · Feasibility testing of the CST-Therapist Companion v2.0. in a post-diagnostic care setting will begin in Q4 2023 in collaboration with the leading CST expert in Denmark, Prof. Rikke Gregersen   · Brain+ expects to have the product ready for sale in H1 2024

Breakthrough Alzheimer’s drug approval seen to renew dementia drug investments and increase the potential for digital dementia therapies – good news for Brain+

Copenhagen, Denmark, July 10, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) · The US FDA has granted full approval to Lecanemab, the first ever disease modifying treatment for early Alzheimer’s disease, invented by BioArctic AB of Sweden and developed by Eisai and Biogen · Lecanemab has shown to slow brain destruction in Alzheimer’s, and after decades of drug failures in the field, experts now see a turning point to renewed investments in dementia drug research and the start of a new era of treatment · Dementia represents an immense unmet need - and there is growing acknowledgement of the role of digital approaches to compliment pharmaceutical treatments in building a more effective dementia ecosystem · Brain+ is a pioneer in the development of evidence-based digital dementia therapeutics to improve cognition in people with early Alzheimer’s dementia, and the recent industry news is seen to increase the company’s potential to attract co-development partnerships

Brain+ presents at the 5[th] Annual DTx (Digital Therapeutics) Europe conference

Copenhagen, Denmark, June 27, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) Brain+ A/S (“BRAINP”) today informed that the company has been invited to participate at the 5[th ]Annual DTx Europe conference to be held in London on June 28[-]29[th]. At the conference, CEO Kim Baden-Kristensen will present a Brain+ case study on ‘Managing the Need for Evidence in a DTx Start-up’, scheduled for June 28[th] at 2:10 p.m. BST (3:10 p.m. CET) and speak on a Keynote Panel Discussion on the topic of ’Is the Clinic Ready for DTx?’, on June 29[th] at 9:00 a.m. BST (10:00 a.m. CET).

Brain+ showcased at Danish Dementia Days and at Altenpflege in Germany, Europe’s largest elderly care conference

Copenhagen, Denmark, May 23, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) · Brain+ was featured at The Dementia Days in Copenhagen, the most important annual dementia event in Denmark with over 1,000 municipal dementia coordinators present · Brain+ was selected as one of the most promising new elderly care technology start-ups at the annual German elderly care conference, Altenpflege   · Conference showcasing is essential to build product awareness and relationships with target customers – and has confirmed growing interest in the Brain+ dementia products  

Brain+ closes its second sales contract for CST – Therapist Companion with a dementia care center in Gladsaxe municipality

Copenhagen, Denmark, May 10, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) · Gladsaxe is the second Danish municipality to have opened for use of CST – Therapist Companion to support Cognitive Stimulation Therapy (CST) for people with dementia · Two contract closings less than 6 months after CST - Therapist Companion was commercially introduced is promising, considering a typical municipal sales cycle of 12-24 months · Denmark is an important reference market for Brain+ with CST gaining widespread recognition

Brain+ Online Investor Update

Copenhagen, Denmark, May 8, 2023 – Brain+ A/S (Nasdaq First North: BRAINP)

Malteser Hilfsdienst and Brain+ begin collaboration to offer people with dementia access to CST in special dementia cafes in Germany

Copenhagen, Denmark, April 21, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) · The first step is a 2-month pilot offering of Brain+’ German version of CST-Therapist Companion in one Malteser dementia café to support care services for people with dementia. · Malteser Hilfsdienst is a key provider of dementia services, and the potential is to expand the use of CST-Therapist Companion to the organization’s 100 dementia cafés around Germany.

Germany sets a new digitalization strategy, further supporting the adoption of digital therapeutics in Europe’s largest healthcare market

Copenhagen, Denmark, March 28, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) · Germany represents a large market potential for Brain+’ digital dementia therapeutics · Brain+ is preparing for commercial introduction of its first digital dementia product, CST-Therapist Companion, in Germany in the 2[nd] quarter of 2023 · As an important healthcare reference country, Germany’s strong digitalization commitment sets the stage for a more rapid adoption of digital therapeutics across Europe

Cognitive Stimulation Therapy (CST) enhances the effects of Alzheimer’s disease medicine

Copenhagen, Denmark, March 24, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) · CST in combination with cholinesterase inhibitors shows to be more effective against dementia in Alzheimer’s disease (AD) than medicine alone · This is promising for combining Brain+ CST products with AD medicine in multi-modal treatment plans to improve health outcomes for patients · Combination treatments could enhance the value of product portfolios for pharmaceutical companies and could thus lead to strategic partnerships for Brain+

Brain+ expands its first sales contract, close to doubling it

Copenhagen, Denmark, March 20, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) · This is important because it shows the potential for growing engagements with customers after an initial contract has been established · The contractual expansion happens only 3 months after the closing of the sale in December 2022 · Denmark is an important reference market for Brain+, and the total municipal market potential for the full future suite of Brain+ CST-based products is estimated at 200 million DKK

Respected dementia experts and Brain+ gets EU grant to research how to optimize digital at-home treatments for people with dementia

Copenhagen, Denmark, March 14, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) · The grant covers research into the two main therapeutic technologies of Brain+, digitalized Cognitive Stimulation Therapy (CST), and Computerized Cognitive Training (CCT). · The grant will also examine the hypothesized synergy effects of combining CST with CCT, which is a key research step for the third Brain+ product in the pipeline, ‘CST-for-MCI’. · University of Gothenburg is hosting the grant, which has a budget of €48,405, and is funded by the EU Joint Programme - Neurodegenerative Disease Research.

New Cochrane review confirms the benefit and relevance of Cognitive Stimulation Therapy (CST) for people with dementia

Copenhagen, Denmark, March 2, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) · Reviews carried out by Cochrane Review Groups are recognized worldwide as the highest standard in evidence-based healthcare · The review shows cognitive benefits of CST corresponding to a 6-month delay in cognitive decline in mild to moderate dementia, and additional improvements in communication and social interaction · Provides further solid support for the increased adoption of CST as a non-pharmaceutical dementia therapy worldwide and for Brain+’ CST-based suite of digital dementia products 

Brain+ showcases its digital dementia products at the Danish-Japanese Welfare and Health Tech Business Conference

Copenhagen, Denmark, February 21, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) · Important opportunity for Brain+ to present its innovative digital solutions for better care and treatment of Alzheimer’s and other types of dementia to key Japanese industry and academic stakeholders. · With a large aging population and more than 4.6 million people living with dementia, Japan has a strong focus on new treatment options and represents a highly attractive market opportunity for Brain+.

Brain+ completes Swedish research version of its dementia product with the Research Institutes of Sweden and extends the collaboration

Copenhagen, Denmark, January 26, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) · A Swedish language version of Cognitive Stimulation Therapy has been created in collaboration with the Research Institutes of Sweden (RISE) in the AD-Shield project. · This will enable further R&D work with our Swedish partner research network, including Research Institutes of Sweden (RISE), University of Gothenburg: the Department of Applied IT, Sahlgrenska Academy, and AgeCap. · An in-house usability study of the CST product at RISE yielded new recommendations for enhancing User Interaction (UI) design further. · Brain+ extended its collaboration with RISE via a key academic partner of Brain+, Associate Professor Rob Lowe, who has moved to RISE, and retains faculty status at the University of Gothenburg.

Results from a clinical study provide promising feasibility indications for Brain+’ CCT technology for cognitive training

Copenhagen, Denmark, January 11, 2023 – Brain+ A/S (Nasdaq First North: BRAINP) • The results of an 8-week placebo-controlled intervention study in people with Subjective Cognitive Impairments (SCI) demonstrated improved cognitive load after the use of Brain+' Computerized Cognitive Training (CCT) games • Some far-transfer effects of the CCT training were also seen in the participant's performance in a shopping task • The indications of clinical feasibility of the CCT technology and the Starry Night cognitive test, provide early support for the Company's pipeline product for Mild Cognitive Impairment, which combines CCT, Starry Night, and Cognitive Stimulation Therapy (CST)

Brain+ closes 2022 with the first municipal sale of its new dementia product and begins the monetization journey

Copenhagen, Denmark, December 31, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) · The sale covers the use of the ‘basic package’ of the CST-Therapist Companion in one training facility for three years, in the municipality of Herning, at an introductory price of 50.000 DKK. · This sale happens already within 2 months of market introduction in what is normally a municipal sales cycle of 6-18 months. A number of customer dialogues are ongoing. · The total market potential in Denmark is valued at 200 million DKK, in the range of ~250.000-10 million DKK per municipality. These estimates are based on the full future portfolio of Brain+ digital dementia products and services.

3-year innovation project with the Danish Life Science Cluster is completed with the Brain+ CST-Therapist Companion product as the final output

Copenhagen, Denmark, December 28, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) · The 3-year ‘CIRCULAR Co-Creation’ project has been the backbone of the development of all the Brain+ Cognitive Stimulation Therapy (CST) products and has resulted in the first Brain+ digital CST prototype, and ultimately in the first Brain+ CST dementia product, the CST-Therapist Companion. · The project has additionally given deep hands-on experience with delivering digital CST to people with dementia, both at home and in group settings in the clinic. This experience has been crucial for adapting the CST-Therapist Companion product to the user's needs and the delivery setting. · In particular, the project involved a team of researchers led by Rikke Gregersen, Ph.D., senior associate professor at the Research Program for Dementia at VIA University College. Rikke Gregersen is a leading expert and key opinion leader on CST in Denmark. Rikke Gregersen has adapted and translated the original English CST manual into Danish and played a key role in bringing CST to Denmark, and in this project in adapting CST to the digital format.

Brain+ announces Investor Webinar following strong Q4 with product launch and successful capital raise

Copenhagen, Denmark, December 22, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) Brain+ invites you to an investor webinar after a strong quarter with commercial introduction of its first dementia product, a successful capital raise, and several supportive market news announcements

Brain+ begins commercial pilot with volunteers from the DaneAge Association

Copenhagen, Denmark, December 16, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) · Volunteers play a key role in caring for people with dementia in target markets like Denmark, Germany, United Kingdom · The pilot project will test the use of the Brain+ product, ‘CST[1]-Therapist Companion’, in a use case where a volunteer facilitates CST sessions with elderlies at home in a one-to-one setting (as opposed to group-based CST). This explores a new commercial opportunity (volunteer services use of CST) and benefits product R&D for the at-home use product, 'CST-Home Care'. · DaneAge (Ældre Sagen), counting 930.000 members, uses volunteers to care for both elderlies and people with dementia

Brain+ completes the implementation of an ISO 13485 Quality Management System for Medical Devices

Copenhagen, Denmark, December 14, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) · Having a standardized Quality Management System in place is a key requirement for the development and commercialization of compliant digital therapeutics · Meeting this milestone supports the company’s objective to attract large pharma partnerships and ensure product reimbursement at scale

A new WHO report points to Cognitive Stimulation Therapy (CST) and digital solutions as means to help solve the global dementia burden

Copenhagen, Denmark, December 9, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) · The WHO report is the second important policy paper in 2022 to have endorsed CST and digital delivery of dementia therapy, which is likely to support the adoption of such solutions, for which the addressable global market is estimated at $5bn[1] · Brain+ is at the forefront of digital therapeutics for dementia and the first to have developed a digital version of CST for its upscaled and wider use and adoption · Brain+ has recently introduced its first digital CST solution in Denmark and expects to have commercial versions ready for Germany in Q2 2023 and the UK next.

Brain+ adds new clinical and development competencies to accelerate and support market access of its digital dementia product portfolio

Copenhagen, Denmark, October 27, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) · Rising star clinical dementia researcher to join the company in a new position as Clinical Director · Recently, development was also strengthened with a Quality Manager and a Clinical Research Associate · The new hires represent a significant competence upgrade and expansion of the clinical team for a more efficient product development and commercialization

Investor Update: Exercise via Nordnet of TO1 warrants possible until October 27[th] 2022

Copenhagen, Denmark October 24, 2022 – Brain+ A/S (Nasdaq First North: BRAINP)

Brain+ further advances its first digital dementia product, Cognitive Stimulation Therapy (CST)-Therapist Companion

Copenhagen, Denmark, October 24, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) · Commercial launch in Denmark will be November 1, 2022 · Adaptation of a UK product version for the United Kingdom starts November 1[st] in collaboration with a key UK CST researcher, the exact launch timing will be announced later.

Brain+ begins early activity and brand building in the US

Copenhagen, Denmark, October 19, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) · The United States (US) is a key future market for Brain+, and early brand building and exploration is now ongoing · Brain+ has been selected and featured as a 2022 TMC-Denmark BioBridge Partner in the new Texas Medical Center (TMC) new 2022 Biobridge e-book. TMC is the largest medical city in the world · 7+ million people ages 65 or older had in the US dementia in 2020 · US reimbursement/price levels for Digital Therapeutics (Dtx) at $1000 and beyond · The US market potential for DTx for dementia is estimated to be more than $2 billion

Brain+ meets the first milestone in its pharma partnership with Rox Health (Roche Germany) on its digital Cognitive Stimulation Therapy products

Copenhagen, Denmark, October 12, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) · Rox Health has approved the German version of Brain+’s first digital dementia product, CST-Therapist Companion, for commercial launch   · Meeting this milestone unlocks access for Brain+ to additional expert resources in the Rox Health/Roche organization and triggers a minor milestone payment · The next milestones will be product launch in Germany, targeted for Q2 2023, and getting the first German customers · The German market for digital dementia therapeutics is estimated at €400 million.

Swedish-based Analyst Group releases first commissioned equity research of Brain+ A/S and base case values the company at DKK 4.1 per share

Copenhagen, Denmark, October 11, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) Swedish-based research group, Analyst Group, which is specialized in life science and technology companies, has today published a 24-page commissioned equity research paper on Brain+, a pioneer in the development of digital therapeutics for Alzheimer’s disease and dementia. They find Brain+ to be “in a strong position to grow towards a market leadership position within Digital Therapeutics for dementia, based on a unique and differentiated product offering [...] combined with a strong clinical pipeline”.

Brain+ informs of new IR initiatives, including initiation of commissioned research, and invites to its first live Investor Update

Copenhagen, Denmark October 11, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) Brain+ A/S (“Brain+”) has upped its investor relations strategy to include a number of new initiatives with the intention to further increase transparency towards investors on the company’s business activities and progress. In addition, the company has made an agreement with AG Equity Research AB (“Analyst Group”) to undertake commissioned equity research.    

World Alzheimer's Report 2022 highlights Cognitive Stimulation Therapy

Copenhagen, Denmark, October 7, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) The recently published World Alzheimer Report 2022 (21. September 2022) highlights Cognitive Stimulation Therapy (CST), the therapy form that Brain+ is digitalizing with global experts, as a cost-effective evidence-based therapy for people with mild-to-moderate dementia that should be researched and implemented globally.

Summary from H1 2022 report: Brain+ (BRAINP) on track for accelerated first dementia product launches in Denmark and Germany in 2022 and 2023

Copenhagen, Denmark, September 29, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) “We are dedicated to helping people with dementia and Alzheimer’s disease as well as their families and caregivers, through the use of our suite of unique and clinically validated Digital Therapeutics. The net financial result in H1 2022 reflects the addition of organizational competencies as well as a higher activity level and was fully in line with expectations. Since the start of the year, our partnership with RoX (part of Roche) has helped identify a faster route to market and fueled accelerated product development of Cognitive Stimulation Therapy – Therapist Companion. Consequently, we have been able to advance commercial launch of the product in Denmark to Q4 this year and in Germany to Q2 2023”, said Kim Baden-Kristensen, CEO of Brain+

Brain+ partners with German medical distributor – and advances launch of its first CST dementia product in Germany to Q2 2023

Copenhagen, Denmark, September 28, 2022 – Brain+ A/S (Nasdaq First North: BRAINP) · Through Coopmed, Brain+ will be represented by experienced and local medical sales managers in Germany and begin to build the customer pipeline in preparation for the commercial launch of its first CST dementia product, CST-Therapist Companion · In partnership with Rox Health (part of Roche Germany), Brain+ has successfully completed the regulatory and commercial preparation of CST-Therapist Companion for the German market and now advances its launch plan with six months to Q2 2023 · The German market for the Brain+ digital CST dementia products is estimated at € 400 million. There are 2,275 nursing homes specialized in dementia in Germany.

Brain+’ new digital product for dementia, “CST–Therapist Companion” is ready for commercial launch in Denmark in Q4 2022 – one year ahead of plan

BRAIN+ A/S (BRAINP) · The Brain+ “CST-Therapist Companion” is a new digital product to deliver Cognitive Stimulation Therapy (CST), a globally recognized evidence-based non-pharmaceutical dementia therapy · The Danish market for the Brain+ digital CST products, of which CST-Therapist Companion is the first, is estimated at € 30 million · CST is used in 35 countries today, and Brain+ is the first to offer a digital version of the therapy

Brain+ is experiencing growing interest from big pharma in its Digital Therapeutics solutions for dementia

Brain+ is a first mover in the field of Digital Therapeutics (DTx) solutions to treat Alzheimer’s Disease (AD) and other types of dementia and help relieve the growing burden of these conditions on patients, relatives, and societies. According to the World Health Organization, currently, more than 55 million people live with dementia worldwide, and there are nearly 10 million new cases every year.

Common Nordic digital health evaluation framework launched

Digital Therapeutics (DTx) is a growing trend and is increasingly a recognized market providing an important supplement to the established trillion USD pharmaceutical market (traditional medicine). The DTx trend is evolving fast. In June 2022 the Nordic Digital Health and Evaluation Criteria (NordDEC) program has been created. The NordDEC is a world-first program to unify digital health standards across multiple countries, delivering safe digital health across Sweden, Denmark, Norway, Finland, and Iceland.

Germany opens the DiPA reimbursement pathway to support the adoption of digital health applications, underpinning the value of the #1 target market for Brain+’ first commercial dementia product, CST

· A significant event for Brain+ as DiPA can provide reimbursement coverage for the first Cognitive Stimulation Therapy (CST) product, expected to be launched in Germany in 2023 · The CST product fits well with the requirements of the DiPA reimbursement pathway. The goal of the DIPA is to reimburse products that stabilize patients' health with special training programs or facilitates communication with family members and nursing care professionals, and this is the same purpose as the product. · The DIPA pathway can thus enable access to the Brain+ CST products for the 1 million Germans living with mild-to-moderate dementia, which is the target segment for the CST products.

1m SEK FORTE grant project to map state of the art digital interventions for dementia begins, helping Brain+ to strengthen patient and caregiver compliance for product development

· PURPOSE: The FORTE project will perform a scoping review of digital interventions for dementia and mild cognitive impairment and engage with live user panels to map out the state-of-the-art in the field. Brain+ focus is to strengthen knowledge on caregiver compliance for product development. Caregiver compliance impacts patient health outcomes and makes the Brain+ digital Cognitive Stimulation Therapy (CST) products scalable. · Brain+ PRODUCT RELEVANCE: The Brain+ dementia treatment product, Cognitive Stimulation Therapy (CST) – Home Extension, which is the 2[nd] product in the CST product line. The product relies on a caregiver to interact with the person with dementia when the CST therapy is done at home.  This is not an issue when CST is done in a clinic, which is the case for the 1[st] product CST – Therapist Companion, where the therapy is led by a trained CST professional.

Summary from Annual Report 2021: Brain+ (BRAINP) is ahead of its IPO plan

“We are dedicated to helping people with dementia and Alzheimer’s disease – their families and their caregivers – through the use of our unique Digital Therapeutic software solutions that are being developed and validated through rigorous scientific and clinical trials. 2021 brought us closer to this core objective and we are now in a strong position to launch our first dementia product in 2023, 2 years ahead of plan. This will be a highly important commercial first step towards leadership in an emerging US billion-dollar market”, said Kim Baden-Kristensen, CEO of Brain+.

Brain+ CTO unfolds the Company’s Technology Platform Strategy

Paula Petcu joined Brain+ as new Chief Technology Officer after the company’s IPO in 2021, and is now driving forth the company’s product development work and technology platform initiatives. She came from Lundbeck A/S, a pioneering pharma company within central nervous system (CNS) disorders, where she built up the digital health organization. In this article, she explains the Brain+ platform strategy and technology stack. Summary highlights · Platform strategy: We are building a technology platform that is both modular, scalable, configurable, and regulatory compliant, while also allowing for high-quality data collection and easy integration with other apps and platforms. · Technology Stack: Our therapeutic software solutions are developed for both web and mobile applications using Flutter, which is a worldwide recognized framework for building multi-platform applications from a single codebase. We build on a German-based cloud infrastructure to ensure compliance with German and European data privacy requirements. And we use a microservices architecture for the flexibility and modularity of our products.

Brain+ selected as ‘digital showcase for Denmark’ by Digital Hub Denmark

Brain+ has been selected as showcase in the HealthTech category, among other top cutting-edge start-ups from Denmark, who are leading the digital transformation of society. The selection of Brain+ is motivated by the company’s achievements and commitment to make effective dementia and Alzheimer’s treatments available to everyone, as digital medicine.

The Danish Foreign Ministry to promote Brain+ into elderly care homes in Germany – Europe’s largest Alzheimer’s market

Brain+ has been identified by the Danish Foreign Ministry as a high potential Danish medtech company relevant for the German market. Therefore, Brain+ has been invited into the Danish-German Care Alliance (Dänisch-Deutsche Pflegeallianz), which aims to put Danish medical technologies directly into the hands of relevant large German customers. In practice, this means that Brain+ will get the opportunity to engage in a structured series of workshops with six large care home chains during 2022 with the aim of establishing local pilots and lead customers for the product launch in 2023.

Brain+ and Biogen preparing for commercialization in Germany, the #1 EU market for digital therapeutics

Brain+ has been selected to Biogen’s and EIT Health’s exclusive Neurotech-prize program. This will give additional momentum to the preparations for launch of Brain+’s first dementia product on the German market in 2023. The German market is a global ‘reference’ market for Digital Therapeutics (DTx) products and succeeding here creates a strong base for global expansion.

Publication of results from an earlier study that showed cognitive improvements in people with Brain Injury after training with Brain+ Recover Computerized Cognitive Training product

BRAIN+ A/S Investor update · Critical, early validation of Brain+ Computerized Cognitive Training technology as effective on specific cognitive outcomes relevant for patients with dementia · Cognitive problems are primary symptoms in pre-stages of dementia and often caused by Alzheimer’s disease · Insights from this study have been built into both the design of Brain+’ new dementia product, Cognitive Stimulation Therapy, and the next generation of cognitive training Brain+ is devoloping to target pre-stages of  dementia in Alzheimer’s patients